Cyclosporin A and Cyclosporin SDZ
نویسنده
چکیده
Recent studies have shown that cyclosporin A (CsA) may affect ricin A-chain immunotoxin (RTA-IT) therapy. In this study, we evaluated the ability of CsA and its nonirnmunosuppressive analog. SDZ PSC 833, to enhance anti-CD5 T l O l RTA-ITS in vitro. Both 4 pmol/L CsA and 4 pmol/L SDZ PSC 833 significantly and specifically enhanced the cytotoxic activity of T101 RTA-IT on the human lymphoblastic T-cell line, CEM Ill (1 01 -fold and 105-fold. respectively). Furthermore, these CS also enhanced the cytotoxicity of the more potent T101 F(abqz RTA-IT (ninefold and eightfold, respectively). The effect of human plasma, originating from four patients enrolled in a phase I high-dose CsA regimen, was examined on T101 RTA-IT cytotoxicity on CEM 111 cells. In each case, with plasma CsA levels be-
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